Abstract

Influenza remains a major public health concern worldwide and is associated with a substantial burden in children, particularly in those with chronic respiratory diseases such as asthma. This brief overview aimed to provide a preliminary examination of the available evidence on parental knowledge, attitudes, and acceptance of influenza vaccination, with a specific focus on children with asthma. The literature showed substantial variability in vaccination uptake, but overall rates were consistently suboptimal. Several factors were associated with higher vaccine acceptance, including healthcare professionals’ recommendations, greater parental awareness of influenza-related risks, trust in vaccine effectiveness, and increased perception of asthma severity. In contrast, poor knowledge, safety concerns, misconceptions about vaccines, and lack of medical advice were the main barriers to vaccination. Some studies also suggested a role for socioeconomic and healthcare access factors, although findings were not always consistent. Overall, parental acceptance of influenza vaccination in children with asthma appears to depend on a combination of clinical, social, and perceptual factors. Enhanced research efforts and targeted educational interventions may help improve vaccine uptake in this high-risk population; however, the current evidence remains limited, and further studies using validated methods are needed to better characterize the determinants of vaccine hesitancy and acceptance over time in this specific context.

References

  1. Macias AE, McElhaney JE, Chaves SS, et al. The disease burden of influenza beyond respiratory illness. Vaccine 2021;15;39(Suppl 1):A6-A14. https://doi.org/10.1016/j.vaccine.2020.09.048.
  2. European Centre for Disease Prevention and Control. https://www.ecdc.europa.eu/en/seasonal-influenza/facts/factsheet.
  3. Barbieri E, Porcu G, Donà D, et al. Epidemiology and Burden of Influenza in Children 0-14 Years Over Ten Consecutive Seasons in Italy. Pediatr Infect Dis J 2023;1:42:e440-446. https://doi.org/10.1097/INF.0000000000004090.
  4. Bella A, Giombini E, Urdiales AM, et al. La sorveglianza integrata dei virus respiratori RespiVirNet in Italia: i risultati della stagione 2023-2024. Boll Epidemiol Naz 2024;5:19-27.
  5. Bonanni P, Conversano M, Icardi G, et al. Strategies to increase influenza vaccination coverage in the Italian pediatric population: a literature review and expert opinion. Expert Rev Vaccines 2025;24:278-288. https://doi.org/10.1080/14760584.2025.2487915.
  6. Marchisio P, Baggi E, Bianchini S, et al. Clinical and socioeconomic impact of pediatric seasonal and pandemic influenza. Hum Vaccin Immunother 2012;8:17-20. https://doi.org/10.4161/hv.8.1.18145.
  7. Ruf BR, Knuf M. The burden of seasonal and pandemic influenza in infants and children. Eur J Pediatr 2014;173:265-276. https://doi.org/10.1007/s00431-013-2023-6.
  8. World Health Organization. Global Influenza Programme. https://www.who.int/teams/global-influenza-programme/vaccines.
  9. Ministero della Salute. Direzione Generale della Prevenzione Sanitaria. Prevenzione e controllo dell’influenza: raccomandazioni per la stagione 2024-2025. https://www.salute.gov.it/new/it/news-e-media/notizie/influenza-pubblicata-la-circolare-con-le-raccomandazioni-la-stagione-2024-2025/.
  10. Ministero della Salute. Direzione Generale della Prevenzione Sanitaria. Prevenzione e controllo dell’influenza: raccomandazioni per la stagione 2020-2021. https://www.salute.gov.it/new/it/news-e-media/notizie/influenza-la-circolare-con-le-raccomandazioni-la-stagione-2020-2021/.
  11. Piano Nazionale di Prevenzione Vaccinale (PNPV) 2023-2025. https://www.epicentro.iss.it/vaccini/piano-nazionale-vaccini-2023-2025.
  12. Homaira N, Briggs N, Oei JL, et al. Impact of influenza on hospitalization rates in children with a range of chronic lung diseases. Influenza Other Respir Viruses 2019;13:233-239. https://doi.org/10.1111/irv.12633.
  13. Schwarze J, Openshaw P, Jha A, et al. Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force. Allergy 2018;73:1151-1181. https://doi.org/10.1111/all.13333.
  14. Macrì F, Gori A, Zicari AM, et al. L’asma nell’adolescente: uno sguardo approfondito sull’impatto fisico ed emotivo. Rivista di Immunologia e Allergologia Pediatrica 2023;37:3-26. https://doi.org/10.53151/2531-3916/2023-335.
  15. Tosca MA, Naso M, Meleca V, et al. Severe asthma: comorbidities and new frontiers in therapy and management. Italian Journal of Pediatric Allergy and Immunology 2024;38:17-19. https://doi.org/10.53151/2531-3916/2024-509.
  16. Licari A, Andrenacci B, Bozzetto S, et al. Comorbidità nell’asma grave pediatrico. Rivista di Immunologia e Allergologia Pediatrica 2022;37:26-39. https://doi.org/10.53151/2531-3916/2023-20.
  17. Ahanchian H, Jones CM, Chen YS, et al. Respiratory viral infections in children with asthma: do they matter and can we prevent them? BMC Pediatr 2012;12:147. https://doi.org/10.1186/1471-2431-12-147.
  18. Busse WW, Lemanske RF Jr, Gern JE. Role of viral respiratory infections in asthma and asthma exacerbations. Lancet 2010;376:826-834. https://doi.org/10.1016/S0140-6736(10)61380-3.
  19. Cataldi JR, O’Leary ST. Parental vaccine hesitancy: scope, causes, and potential responses. Curr Opin Infect Dis 2021;34:519-526. https://doi.org/10.1097/QCO.0000000000000774.
  20. MacDonald NE; SAGE Working Group on Vaccine Hesitancy. Vaccine hesitancy: Definition, scope and determinants. Vaccine 2015;33:4161-4164. https://doi.org/10.1016/j.vaccine.2015.04.036.
  21. Jiménez-García R, Hernández-Barrera V, Carrasco-Garrido P, et al. Coverage and predictors of adherence to influenza vaccination among Spanish children and adults with asthma. Infection 2010;38:52-57. https://doi.org/10.1007/s15010-009-9069-4.
  22. Soyer OU, Hudaverdiyev S, Civelek E, et al. Parental perspectives on influenza vaccination in children with asthma. Pediatr Pulmonol 2011;46:139-144. https://doi.org/10.1002/ppul.21332.
  23. Kaya A, Altınel N, Karakaya G, et al. Knowledge and attitudes among patients with asthma and parents and physicians towards influenza vaccination. Allergol Immunopathol (Madr) 2017;45:240-243. https://doi.org/10.1016/j.aller.2016.08.003.
  24. Al-Qerem W, Jarab A, Hammad A, et al. Knowledge, Attitudes, and Practices of Influenza Vaccination among Parents of Children with Asthma: A Cross-Sectional Study. Vaccines (Basel) 2023;11:1074. https://doi.org/10.3390/vaccines11061074.
  25. Gnanasekaran SK, Finkelstein JA, Hohman K, et al. Parental perspectives on influenza vaccination among children with asthma. Public Health Rep 2006;121:181-188. https://doi.org/10.1177/003335490612100213.
  26. Özer M, Başkaya N, Bostancı İ. Attitudes towards influenza and pneumococcal vaccines in parents of asthmatic children during the COVID-19 pandemic. Pediatr Pulmonol 2022;57:871-877. https://doi.org/10.1002/ppul.25818.
  27. Buyuk Yaytokgil S, Sen G, Metbulut AP, et al. Parental Concerns and Attitudes Regarding Influenza Vaccination of Children with Asthma During the COVID-19 Pandemic. Asthma Allergy Immunol 2023;21:199-206. http://doi.org/10.21911/aai.266.
  28. Schmid P, Rauber D, Betsch C, et al. Barriers of Influenza Vaccination Intention and Behavior - A Systematic Review of Influenza Vaccine Hesitancy, 2005-2016. PLoS One 2017;12:e0170550. https://doi.org/10.1371/journal.pone.0170550.
  29. Istituto Superiore di Sanità (ISS). EpiCentro. https://www.epicentro.iss.it/influenza/coperture-vaccinali.
  30. Kassianos G, Cohen JM, Civljak R, et al. The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel. Expert Rev Respir Med 2024;18:69-84. http://doi.org/10.1080/17476348.2024.2340470.
  31. European Centre for Disease Prevention and Control. https://www.ecdc.europa.eu/sites/default/files/media/en/publications/Publications/vaccine-hesitancy-among-healthcare-workers.pdf.
  32. AlQurashi A, Aljishi H, Demyati E. Parental Perception Towards Flu Vaccination for Asthmatic Children in Saudi Arabia. Cureus 2019;11:e6460. http://doi.org/10.7759/cureus.6460.

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Authors

Marianna Riccio - Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy

Anna Maria Zicari - Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy

Marzia Duse - Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy

How to Cite
Riccio, M., Zicari, A. M., & Duse, M. (2026). Acceptance of Influenza Vaccination in Asthmatic Children: What Does the Evidence Show?. Italian Journal of Pediatric Allergy and Immunology, 40(1), 52–54. https://doi.org/10.53151/2531-3916/2026-2244
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