Abstract

Allergen immunotherapy (AIT) remains the only disease-modifying treatment for IgE-mediated disorders. The combination of AIT with biologic agents represents a promising therapeutic approach, offering enhanced efficacy, safety and clinical outcomes in the management of severe allergic conditions such as food allergy, asthma, rhinitis and hymenoptera venom allergy. Notably, existing evidence in pediatric populations predominantly focuses on omalizumab. However, there are no standardized protocols for the combined use of AIT and biological drugs.

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Authors

Chiara Ferrecchi - Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy https://orcid.org/0009-0008-7948-9051

Vincenzo Meleca - Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy

Matteo Naso - Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy

Chiara Trincianti - Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy

Roberta Olcese - Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy

Maria Angela Tosca - Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy

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Copyright (c) 2026 Italian Journal of Pediatric Allergy and Immunology

How to Cite
Ferrecchi, C., Meleca, V., Naso, M., Trincianti, C., Olcese, R. ., & Tosca, M. A. (2026). Allergen Immunotherapy and Biologics. Italian Journal of Pediatric Allergy and Immunology, 39(4). https://doi.org/10.53151/2531-3916/2025-1688
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