Abstract

Food-dependent exercise-induced anaphylaxis (FDEIA) represents a rare allergic condition in which anaphylaxis is triggered only by the combination of eating specific foods and subsequent physical activity, often influenced by cofactors such as NSAIDs, alcohol, or infections. The pathophysiology involves increased intestinal permeability, enhanced allergen absorption, and immune dysregulation. Management emphasizes acute treatment and, crucially, prevention through patient education and cofactor control. Preliminary evidence supports the role of biologics, such as omalizumab and dupilumab, and oral immunotherapy in selected patients

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Aleksandra Zomerfeld - Pediatric and Neonatology Unit, Imola Hospital, Imola, Italy

Irene Bettini - Pediatric and Neonatology Unit, Imola Hospital, Imola, Italy

Paolo Bottau - Pediatric and Neonatology Unit, Imola Hospital, Imola, Italy

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Zomerfeld, A., Bettini, I., & Bottau, P. (2025). Food-Dependent Exercise-Induced Anaphylaxis: Current Insights and Future Directions. Italian Journal of Pediatric Allergy and Immunology, 39(3). https://doi.org/10.53151/2531-3916/2025-1584
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