Esofagite eosinofila: una revisione per il clinico

Antonella Cianferoni

Division of Allergy and Immunology, The Children’s Hospital of Philadelphia, Pennsylvania; Perelman School of Medicine at University of Pennsylvania, USA

Eosinophilic Esophagitis (EoE) is a chronic atopic clinical-pathologic disease that causes symptoms such as difficulties in feeding, vomiting, abdominal pain, dysphagia sue to an esophageal dysfunction and/or fibrosis caused by a T helper type 2 (Th2) inflammation triggered often by food allergens. EoE diagnosis is confirmed if the esophageal biopsy shows at least 15 eosinophils per high power field (eos/hpf). Once EoE is diagnosed endoscopically, is very important to treat the local eosinophilic inflammation not only to control symptoms, but also to prevent complications such as esophageal stricture and food impaction. The conventional therapy of EoE is based on the use of topical steroids or food antigen avoidance.

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